The letters in EXPRESS make 51 words of two letters or more. The longest is EXPRESS at 7 letters, and the highest-scoring is EXPRESS at 16 points.
No other single word uses all 7 letters of EXPRESS. EXPRESS has 7 letters: 2 vowels and 5 consonants, worth 16 points before any board bonuses.
7-letter words 1
6-letter words 4
perses8prexes15speers8sprees8
5-letter words 12
erses5peers7perse7prees7prese7press7rexes12seeps7seers5seres5speer7spree7
4-letter words 14
eses4esse4exes11peer6pees6pree6prex13rees4reps6seep6seer4sees4sere4sers4
3-letter words 12
ere3ers3ess3pee5per5pes5ree3rep5res3rex10see3ser3
2-letter words 8
er2es2ex9pe4ps4re2rs2ss2
Words are from our open word list and include some game-only words. Rude words are left out of this page; the unscrambler shows every valid word, lets you add blank tiles and filter by length.