The letters in ISOLATION make 222 words of two letters or more. The longest is ISOLATION at 9 letters, and the highest-scoring is ISOLATION at 9 points.
No other single word uses all 9 letters of ISOLATION. ISOLATION has 9 letters: 5 vowels and 4 consonants, worth 9 points before any board bonuses.
9-letter words 1
8-letter words 2
inositol8solation8
7-letter words 5
latinos7liaison7lotions7soliton7talions7
6-letter words 16
aiolis6aloins6instal6instil6isatin6latino6lotion6saloon6santol6solano6solion6stolon6talion6talons6tolans6tonsil6
5-letter words 49
aioli5alist5aloin5altos5anils5antis5intis5iotas5linos5lints5lions5litai5litas5loans5loins5loons5loots5lotas5lotos5nails5noils5nolos5notal5olios5ostia5saint5salon5santo5satin5slain5slant5snail5snool5snoot5solan5solon5sotol5stain5stoai5stool5tails5tains5talon5toils5tolan5tolas5tonal5tools5toons5
4-letter words 82
ails4ains4aits4alit4also4alto4alts4anil4anis4anti4ants4ilia4inia4inti4into4ions4iota4lain4last4lati4lats4lino4lins4lint4lion4list4lits4loan4loin4loon4loos4loot4lost4lota4loti4lots4nail4naoi4naos4nils4nisi4nits4noil4nolo4nota4oast4oats4oils4olio4onto4oots4sail4sain4salt4sati4sial4silo4silt4slat4slit4slot4snit4snot4soil4sola4soli4solo4soon4soot4stoa4tail4tain4tali4tans4taos4tils4tins4toil4tola4tons4tool4toon4
3-letter words 42
ail3ain3ais3ait3als3alt3ani3ant3ins3ion3its3las3lat3lin3lis3lit3loo3lot3nil3nit3noo3nos3not3oat3oil3ons3oot3sal3sat3sin3sit3sol3son3sot3tan3tao3tas3til3tin3tis3ton3too3
2-letter words 25
ai2al2an2as2at2in2is2it2la2li2ln2lo2ls2na2no2oi2on2oo2os2si2so2ta2ti2to2ts2
Words are from our open word list and include some game-only words. Rude words are left out of this page; the unscrambler shows every valid word, lets you add blank tiles and filter by length.