The letters in MULTIPLES make 306 words of two letters or more. The longest is MULTIPLES at 9 letters, and the highest-scoring is MULTIPLES at 13 points.
No other single word uses all 9 letters of MULTIPLES. MULTIPLES has 9 letters: 3 vowels and 6 consonants, worth 13 points before any board bonuses.
9-letter words 1
8-letter words 4
7-letter words 14
illumes9impetus11impulse11imputes11limpest11limpets11millets9mullets9mullite9pilules9pullets9stipule9tuilles7uptimes11
6-letter words 27
illest6illume8impels10impute10letups8limpet10listel6litmus8milles8millet8muesli8mullet8pileum10pileus8pilule8plumes10plutei8pullet8septum10simple10stipel8telium8tuille6tulips8tulles6tuples8uptime10
5-letter words 83
emits7etuis5ileum7ileus5impel9islet5istle5items7letup7lieus5lilts5limes7limps9lisle5lumps9lutes5mells7melts7metis7miles7mille7mills7milts7mites7mules7mulls7multi7mutes7pelts7piles7pills7pilus7piste7plies7plume9plums9pules7pulis7pulls7pulse7setup7situp7slept7slime7slipe7slipt7slump9smell7smelt7smile7smite7speil7spell7spelt7spiel7spile7spill7spilt7spite7split7spume9stile5still5stime7stipe7stull5stump9stupe7suite5tells5tempi9temps9tiles5tills5times7tules5tulip7tulle5tumps9tuple7uplit7upset7utile5
4-letter words 99
ells4elms6emit6emus6etui4ills4imps8isle4item6leis4lept6lest4lets4lies4lieu4lilt4lime6limp8lips6lisp6list4lite4lits4litu4lues4lump8lums6lust4lute4mell6mels6melt6mile6mill6mils6milt6mise6mist6mite6mule6mull6muse6must6mute6muts6pelt6pest6pets6pies6piet6pile6pill6pits6plie6plum8plus6pule6puli6pull6puls6puts6sell4semi6sept6sill4silt4simp8sipe6site4slim6slip6slit4slue4slum6smit6spit6spue6stem6step6stum6suet4suit4sump8supe6tell4tels4temp8ties4tile4till4tils4time6tips6tuis4tule4tump8tums6tups6umps8
3-letter words 55
ell3elm5els3ems5emu5ill3imp7ism5its3lei3let3leu3lie3lip5lis3lit3lum5mel5mes5met5mil5mis5mus5mut5pes5pet5pie5pis5pit5piu5psi5pul5pus5put5sei3sel3set3sim5sip5sit3sue3sum5sup5tel3tie3til3tip5tis3tui3tum5tup5ump7ups5use3uts3
2-letter words 23
el2em4es2et2is2it2li2lm4ls2me4mi4ms4mu4pe4pi4ps4si2ti2ts2um4up4us2ut2
Words are from our open word list and include some game-only words. Rude words are left out of this page; the unscrambler shows every valid word, lets you add blank tiles and filter by length.