The letters in NATURE make 68 words of two letters or more. The longest is NATURE at 6 letters, and the highest-scoring is NATURE at 6 points.
No other single word uses all 6 letters of NATURE. NATURE has 6 letters: 3 vowels and 3 consonants, worth 6 points before any board bonuses.
6-letter words 1
5-letter words 3
antre5tuner5urate5
4-letter words 20
ante4aunt4earn4etna4near4neat4rant4rate4rent4rune4runt4tare4tarn4tear4tern4true4tuna4tune4turn4urea4
3-letter words 30
ane3ant3are3art3ate3ear3eat3eau3era3ern3ert3eta3nae3net3nut3ran3rat3ret3rue3run3rut3tae3tan3tar3tau3tea3ten3tun3urn3uta3
2-letter words 14
ae2an2ar2at2en2er2et2na2ne2nu2re2ta2un2ut2
Words are from our open word list and include some game-only words. Rude words are left out of this page; the unscrambler shows every valid word, lets you add blank tiles and filter by length.