The letters in SYNDROME make 224 words of two letters or more. The longest is SYNDROME at 8 letters, and the highest-scoring is SYNDROME at 14 points.
No other single word uses all 8 letters of SYNDROME. SYNDROME has 8 letters: 2 vowels and 6 consonants, worth 14 points before any board bonuses.
8-letter words 1
7-letter words 2
moderns10rodsmen10
6-letter words 14
demons9doyens10drones7modern9mondes9moneys11normed9redons7rodmen9sermon8snored7sonder7sorned7yonder10
5-letter words 48
demon8demos8derms8doers6domes8donsy9dorms8dormy11doser6doyen9drone6dyers9dynes9emyds11enorm7mends8meson7modes8monde8money10mores7morns7morse7mosey10nerds6nerdy9nodes6nomes7norms7nosed6nosey8omens7omers7onery8oyers8redon6redos6rends6resod6ronde6rosed6rynds9senor5snore5sonde6synod9syren8yores8
4-letter words 77
demo7demy10dens5deny8derm7deys8doer5does5dome7doms7done5dons5dore5dorm7dors5dory8dose5drys8dyer8dyes8dyne8emos6emyd10ends5eons4erns4eros4mend7meno6mode7mods7mons6mony9more6morn6mors6nerd5node5nods5noes4nome6noms6norm6nose4nosy7odes5omen6omer6ones4ores4oyer7oyes7redo5reds5rems6rend5rode5rods5roes4roms6rose4rosy7ryes7rynd8send5sned5snye7some6sone4sord5sore4sorn4syne7yens7yods8yond8yore7
3-letter words 57
den4dey7doe4dom6don4dor4dos4dry7dye7emo5ems5end4ens3eon3ern3ers3med6men5mes5mod6mon5mor5mos5mys8nod4nom5nor3nos3ode4ods4oes3oms5one3ons3ore3ors3ose3red4rem5res3rod4roe3rom5rye6sen3ser3sod4som5son3soy6syn6yen6yer6yes6yod7yom8yon6
2-letter words 25
de3do3ed3em4en2er2es2me4mo4ms4my7ne2no2od3oe2om4on2or2os2oy5re2rs2so2ye5yo5
Words are from our open word list and include some game-only words. Rude words are left out of this page; the unscrambler shows every valid word, lets you add blank tiles and filter by length.